The emergence and spread of Mycobacteria resistant to multiple anti-tuberculosis drugs is of global concern. To improve the understanding of drug resistance in Mycobacteria, numerous studies were performed to detect diagnostic markers and genetic determinants. However, the relative information is scattered in massive literatures, which is inconvenient for researchers to investigate and control resistant Mycobacteria strains. Therefore, we manually collected 1,707 curated associations between 73 compounds and 132 molecules in 6 species (including M. tuberculosis, M. smegmatis, M. bovis, M. marinum, M. leprae, and M. abscessus) from both molecular epidemiology and mechanism exploration research. Furthermore, epidemiological information and molecule changes of clinical multidrug-resistant and extensively drug-resistant isolates were compiled in this work. Finally, an omnibus repository named MycoResistance was constructed, which furnished a user-friendly interface to conveniently browse, search and download relevant information. With the rapidly increasing interest in precision medicine in Mycobacteria, our resource will significantly improve understanding of molecular mechanisms involved in drug resistance, and has the potential to be a timely and valuable resource.
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MycoResistance: A Curated Resource of Antibiotic Resistance Molecules in Mycobacteria